Publications

  • Staecker H, Morelock M, Kramer T, Chrbolka P, Ahn J, Meyer T (2017): Safety of Repeated-Dose Intratympanic Injections with AM-101 in Acute Inner Ear Tinnitus, Otolaryngology–Head and Neck Surgery
    Open access
  • Mühlmeier G, Baguley D, Cox T, Suckfüll M, Meyer T (2016): Characteristics and spontaneous recovery of tinnitus related to idiopathic sudden sensorineural hearing loss, Otology & Neurotology 37(6), 634–641..
    Open access
  • Staecker H, Maxwell KS, Morris JR, van de Heyning P, Morawski K, Reintjes F, Meyer T (2015): Selecting appropriate dose regimens for AM-101 in the intratympanic treatment of acute inner ear tinnitus, Audiology and Neurotology 20(3), 172-182.
    Open access
  • Bing D, Lee SC, Campanelli D, Xiong H, Matsumoto M, Panford-Walsh R, Wolpert S, Praetorius M, Zimmermann U, Chu H, Knipper M, Rüttiger L, Singer W (2015): Cochlear NMDA receptors as a therapeutic target of noise-induced tinnitus, Cellular Physiology and Biochemistry 35(5), 1905-1923.
    Open access
  • Suckfuell M, Lisowska G, Domka W, Kabacinska A, Morawski K, Bodlaj R, Klimak P, Kostrica R, Meyer T (2014): Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: a double-blind, randomized, placebo-controlled phase II study, Otology & Neurotology 35(8), 1317-1326.
    Open access
  • Van de Heyning P, Muehlmeier G, Cox T, Lisowska G, Maier H, Morawski K, Meyer T (2014): Efficacy and safety of AM-101 in the treatment of acute inner ear tinnitus – a double-blind, randomized, placebo-controlled phase II study, Otology & Neurotology 35(4), 589-597.
    Open access
  • Eshraghi AA, Gupta C, Van De Water TR, Bohorquez JE, Garnham C, Bas E, Talamo VM (2013): Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-Jun-N-terminal kinase signaling, Laryngoscope 123 (Suppl 1), S1-S14.
    Abstract
  • Meyer T (2013): Intratympanic treatment for tinnitus: a review, Noise & Health 15(63), 83-90.
    Open access
  • Omotehara Y, Hakuba N, Hato N, Okada M, Gyo K (2011): Protection Against Ischemic Cochlear Damage by Intratympanic Administration of AM-111, Otology & Neurotology 32(9), 1422-1427.
    Abstract
  • Muehlmeier G, Biesinger E, Maier H (2011): Safety of intratympanic injection of AM-101 in patients with acute inner ear tinnitus, Audiology & Neurotology 16(6), 388-397.
    Abstract
  • Grindal TC, Sampson EM, Antonelli PJ (2010): AM-111 prevents hearing loss from semicircular canal injury in otitis media, Laryngoscope 120, 178-182.
    Abstract
  • Barkdull GC, Hondarrague Y, Meyer T, Harris JP, Keithley EM (2007): AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis, Laryngoscope 117, 2174-2182.
    Abstract
  • Suckfuell M, Canis M, Strieth S, Scherer H, Haisch A (2007): Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study, Acta Oto-Laryngologica 127(9), 938-942.
    Abstract
  • Wang J, Ruel J, Ladrech S, Bonny C, Van de Water TR, Puel JL (2007): Inhibition of the JNK-mediated mitochondrial cell death pathway restores auditory function in sound exposed animals, Molecular Pharmacology 71(3), 654-666.
    Abstract
  • Eshraghi AA, Wang J, Adil E, He J, Zine A, Bublik M, Bonny C, Puel JL, Balkany TJ, Van De Water TR (2007): Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity, Hearing Research 226(1-2), 168-177.
    Abstract
  • Eshraghi AA, He J, Mou CH, Polak M, Zine A, Bonny C, Balkany TJ, Van de Water TR (2006): D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma, Otology & Neurotology 27(4), 504-511.
    Abstract
  • Coleman JK, Littlesunday C, Jackson R, Meyer T (2007): AM-111 protects against permanent hearing loss from acute acoustic trauma, Hearing Research 226, 70-78.
    Abstract
  • Zine A, Van de Water TR (2004): The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness, Current Drug Targets CNS and Neurological Disorders 3(4), 325-332.
    Abstract
  • Wang J, Ladrech S, Pujol R, Brabet P, Van De Water TR, Puel JL (2004): Caspase inhibitor, but not a c-Jun kinase peptide inhibitor, can prevent cisplatin-induced hearing loss, Cancer Research 64, 9217-9224.
    Abstract
  • Van De Water TR, Zine A, Eshraghi AA, Mou CH, Wang J, Puel JL, Balkany TJ (2004): Inhibition of the MAPK/JNK signal cascade protects hearing and auditory sensory cells against ototoxins and sound trauma: can it conserve residual hearing during cochlear implantation?, International Congress Series 1273, 72-75.
    Abstract
  • Wang J, Van De Water TR, Bonny C, Ribaupierre F, Puel JL, Zine A (2003): A peptide inhibitor of c-Jun N-terminal kinase (D-JNKI-1) protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss, J. Neuroscience 23, 8596-8607.
    Abstract